N-Glycolylneuraminic acid

Research use only, not for human use.

N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.

N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.(In Vitro):Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells.

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NeuGc | GcNeu

Microbiology/Virology

Influenza Virus

Human Endogenous Metabolite

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1113-83-3

325.27

C11H19NO10

>98% (HPLC)

In Vitro:?H2O : 83.33 mg/mL (256.19 mM)

OC[C@@H](O)[C@@H](O)[C@@H]1O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years